Biochem/physiol Actions

Reversible: yes

Cell permeable: yes

Primary TargetCXCR7

General description

A styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pK_i = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC₅₀ = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wijtmans, M., et al. 2011, Eur J Med Chem51, 184.

Packaging

Packaged under inert gas

10 mg in Glass bottle

Warning

Toxicity: Standard Handling (A)