General description

TdT (terminal deoxynucleotidyl transferase) is a template-independent DNA polymerasethat adds nucleotides randomly to single-stranded DNA. This randomization plays a role inacquired immunity by increasing antigen receptor diversity and aiding in the generation ofimmunoglobulins and T-cell antigen receptors. TdT immunoreactivity is observed mainly in the thymus. Anti-TdT is often used to visualize lymphoblastic lymphomas and has also beenobserved in some cases of acute myeloid leukemia.

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

TdT Positive Control Slides, Product No. 338S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide

Preparation Note

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Quality