Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Cell permeable: yes

Target IC₅₀: 0.5 µM against GSK-3β

General description

A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, selective, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 500 nM). Does not affect the activity of PKA even at concentrations as high as 100 µM.

A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 0.5 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Conde, S., et al. 2003. J. Med. Chem.46, 4631.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)