Biochem/physiol Actions
Primary Target5-HT2A
General description
A selective 5-HT2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT2AR (Ki = 1.49 nM) relative to other family members like 5-HT2BR (Ki = 740 nM) and 5-HT2CR (Ki = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity.
A selective 5-HT2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT2AR (Ki = 1.49 nM) relative to other family members like 5-HT2BR (Ki = 740 nM) and 5-HT2CR (Ki = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Ros, R. et al. 2013. PNAS.110, 348.r>Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol.406, 163.Leysen, J. E. et al. 1981. Life Sci.28, 1015.
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Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Toxic (F)
This product has met the following criteria: