Application
Okadaic acid from Prorocentrum concavum has been used as a phosphatase inhibitor:to inhibit protein phosphatase 2 in spermatocytes cultureto treat SH-SY5Y cells to prevent dephosphorylation to maintain tauto treat human embryonic kidney 293T cells (HEK293T) or H4 cells to analyse its effect on fused in sarcoma (FUS) protein
Biochem/physiol Actions
Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.
Features and Benefits
This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
General description
Okadaic acid is a polyether fatty acid. It is a marine toxin produced by the genera of ProrocentrumandDinophysis.
Preparation Note
Isolated from unialgal cultures of dinoflagellates.
This product has met the following criteria: