Biochem/physiol Actions

Primary TargetPotent central nervous system stimulant

Cell permeable: no

Reversible: no

Product does not compete with ATP.

General description

Trimethylated xanthine that acts as a potent central nervous system stimulant. A nonselective phosphodiesterase inhibitor. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca²⁺ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by camptothecin and topotecan in HL-60 cells.

Trimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca²⁺ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by Camptothecin (Cat. No. 208925) and topotecan in HL-60 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Zhen, W., and Vaugha, A. T. 1995. Radiat. Res.141, 170.Howell, L. L. 1993. Cancer Res.54, 4993.Traganos, F., et al. 1993. Cancer Res.53, 4613.Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.

Packaging

500 g in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)