Voriconazole, VETRANAL, analytical standard

Code: 32483-25MG D2-231

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.


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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.

It has been used as one of the constituent of YPD (1% yeast extract, 2% peptone, 2% glucose) liquid media.

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-a sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.

General description

Voriconazole is a second-generation triazole, and is derived from fluconazole. It has a broad and enhanced antifungal spectrum as compared to other older triazoles. It is mostly well tolerated and is available in both oral and intravenous formulations.

Legal Information

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

application(s)forensics and toxicologypharmaceutical (small molecule)
formatneat
gradeanalytical standard
InChI keyBCEHBSKCWLPMDN-MGPLVRAMSA-N
InChI1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
product lineVETRANAL®
Quality Level100
shelf lifelimited shelf life, expiry date on the label
SMILES stringC[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F
technique(s)gas chromatography (GC): suitable, HPLC: suitable
Cas Number137234-62-9
Hazard Class6.1
Un Number2811
Pack GroupIII
This product has met the following criteria: