Biochem/physiol Actions
Primary TargetSerine palmitoyltransferase
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Target Ki: 280 pM against serine palmitoyltransferase
General description
A potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Hanada, K., et al. 2000. Biochem. Pharmacol.59, 1211.Chen, J.K., et al. 1999. Chem. Biol. 6, 221.Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.Fujita, T., et al. 1994. J. Antibiot. 47, 208.
Packaging
5 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Harmful (C)
This product has met the following criteria: