Biochem/physiol Actions

Primary TargetSerine palmitoyltransferase

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Target K_i: 280 pM against serine palmitoyltransferase

General description

A potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; K_i = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Hanada, K., et al. 2000. Biochem. Pharmacol.59, 1211.Chen, J.K., et al. 1999. Chem. Biol. 6, 221.Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.Fujita, T., et al. 1994. J. Antibiot. 47, 208.

Packaging

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)