Biochem/physiol Actions
Cell permeable: no
Reversible: no
Primary TargetNa+,K+-ATPase
Product does not compete with ATP.
General description
Inhibits Na+,K+-ATPase. Exhibits cardiotonic properties. Preferentially enhances radiotoxicity in tumor cells and induces apoptosis by prolonging the irradiation-induced G2 delay.
Inhibits Na+ and K+-dependent ATPases. Has cardiotonic properties.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.Hasenauer, J., et al. 1993. J. Biol. Chem.268, 3289.Rakowski, F.F. 1993. J. Gen. Physiol.101, 117.Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry31, 2025.Xu, Z.J., et al. 1992. J. Physiol.456, 405.
Packaging
1 g in Glass bottle
Reconstitution
Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.
Warning
Toxicity: Toxic (F)
This product has met the following criteria: