Biochem/physiol Actions

Primary Target5-HT_2A

General description

A selective 5-HT_2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT_2AR (K_i = 1.49 nM) relative to other family members like 5-HT_2BR (K_{i = 740 nM) and 5-HT2CR (Ki = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity.}

A selective 5-HT_2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT_2AR (K_i = 1.49 nM) relative to other family members like 5-HT_2BR (K_i = 740 nM) and 5-HT_2CR (K_i = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT_2AR and 5-HT_2CR activity.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ros, R. et al. 2013. PNAS.110, 348.r>Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol.406, 163.Leysen, J. E. et al. 1981. Life Sci.28, 1015.

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Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Toxic (F)