Application

Zotepine has been used as an anti-psychotic agent:in biophysical studies with serotonin 2A receptor (5-HT_2AR)to study its effects on the inhibition of human organic cation transporter 1 (hOCT1)to study its protective effects on the human embryonic kidney (HEK cells)

Biochem/physiol Actions

Zotepine is an atypical antipsychotic.

Zotepine acts as an antagonist of dopamine D1, D2, and serotonin (5-HT_2A/2C) receptors, and noradrenalinetransporters. It shows therapeutic effects against schizophrenia and acute mania.

Features and Benefits

This compound was developed by Astellas. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. Z0877.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Packaging

10, 50 mg in glass bottle