Application

Hemocyanin, Keyhole Limpet, Megathura crenulata, high purity, endotoxin-free, sterile-liquid has been used as an antigen to test the polyreactivity of monoclonal antibody (mAb)using enzyme-linked immunosorbent assay(ELISA). It has also been used to immunize animals to study KLH-specific ex vivo recall responses and specific T-cell dependent antibody response (TDAR) in monkeys.

Biochem/physiol Actions

Keyhole limpethemocyanin(KLH)stimulates both cell-mediated and humoral responses in animals and humans. It elicits immunostimulatory properties and also functions as a vaccine adjuvant.KLH serves as a carrier proteinto produceantibodiesandhaptenslike peptides and oligosaccharides. Itis used to treat bladder cancer.

General description

Keyhole limpet hemocyanin (KLH) is a large, multi-subunit, O2-carrying, metalloprotein. This high molecular weight glycoprotein is extracted from a marine snail species called Megathura crenulate.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Packaging

25 mg in Plastic ampoule

Please refer to vial label for lot-specific concentration.

Physical form

In 83 mM sodium phosphate, 150 mM NaCl, pH 7.2.

Warning

Toxicity: Standard Handling (A)