General description

Recombinant, mouse α-interferon expressed in E. coli. Antiviral, antineoplastic agent. Expressed during the triggering stage of macrophage cytocidal activation. Suppresses bone marrow function and cell proliferation. Modulates the immune response. Also known to induce apoptotic cell death in non-melanoma skin cancer.

Recombinant, mouse α-interferon expressed in E. coli. Antiviral and anti-neoplastic agent. Suppresses bone marrow function and induces apoptotic cell death in non-melanoma skin cancer. IFN-α signaling is mediated by JAK1 and TYK2 tyrosine kinases. Note: 1 KU = 1000 units.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Krishnan, K., et al. 1997. Eur. J. Biochem. 247, 298.Rodriquez-Villanueva, S., and McDonnel, T.J. 1995. Int. J. Cancer61, 110.Dianzani, F. 1993. Gut34, 574.Brouty-Boyce, D., and Zetter, B.R. 1990. Science208, 516.Sidky, Y.A., and Borden, E.C. 1987. Cancer Res.47, 5155.Daugherty, B.L., and Pestka, S. 1986. Methods Enzymol.119, 34.Pestka, S. 1986. Methods Enzymol.119, 14.Familletti, P.C., et al. 1981. Methods Enzymol.78, 387.Johnson, M.D., et al. 1981. Methods Enzymol.78, 394.Rubinstein, S., et al. 1981. J. Virol.37, 755.

Packaging

100 ku in Plastic ampoule

Unit Definition

One unit of interferon per ml of medium will cause a 50% inhibition of EMCV-induced cytopathic effect on mouse L929 cells. Units are determined with respect to the NIH international reference standard for mouse IFN-α.

Warning

Toxicity: Standard Handling (A)