General description

A cell-permeable, water-soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide, and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. Acts as a selective agonist of TLR2 (Toll-like receptor 2).

A cell-permeable, water-soluble, synthetic, cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation, and activates ERK1/2 and MEK1/2. Acts as a selective TLR-2 (Toll-like receptor 2) agonist.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Barrenschee, M., et al. 2010. PLoS One.5, e13889.Zahringer, U., et al. 2008. Immunology.213, 205.Toshchakov, V., et al. 2002. Nat. Immunol.3, 392.Muller, M.R., et al. 2001. Immunology103, 49.Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem.264, 369.Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem.271, 30114.Offermanns, S., et al. 1992. Biochem. J.282, 551.Seifert, R., et al. 1990. Biochem. J.267, 795.Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler.370, 575.

Packaging

2 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.

Warning

Toxicity: Standard Handling (A)