General description

Recombinant, human α-synuclein expressed in E. coli. An acidic neuronal protein consisting of 140 amino acids that has been implicated in the pathogenesis of Parkinson′s disease and related neurodegenerative disorders. Also reported to be an important regulatory component of vesicular transport in neuronal cells. The apparent molecular weight by SDS-PAGE is ~19-20 kDa.

Recombinant, human α-synuclein expressed in E. coli. α-Synuclein is an acidic neuronal protein of 140 amino acids (amino acid residues 1 -140). This enzyme has been implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kahle, P.J, et al. 2001. Am. J. Pathol.159, 2215.Kim, J. 1997. Mol. Cells7, 78.Paik, S.R. 1997. Arch. Biochem. Biophys.344, 325.Jakes, R., et al. 1994. FEBS Lett.345, 27.Ueda, K., et al. 1993. Proc. Natl. Acad. Sci. USA90, 11282.

Packaging

200 µg in Plastic ampoule

Please refer to vial label for lot-specific concentration.

Physical form

In 100 mM NaCl, 20 mM Tris-HCl, 1 mM MgCl₂, pH 7.5.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Warning

Toxicity: Standard Handling (A)