Application

Rabbit Anti-Aflatoxin B1 antibody has been used for the development of electrochemical immunosensors. The antibody has also been used in designing novel sandwich immunoassays. The product can also be used for capture ELISA at a dilution of 1:1,000.

Biochem/physiol Actions

Aflatoxin B₁ and its metabolites act as potent carcinogens, mutagens and teratogens. Aflatoxins have been implicated in human hepatocellular carcinoma, outbreaks of aflatoxicosis, Rey′s syndrome, chronic hepatitis and increased mortality from infection in animal husbandry.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The antibody reacts with the B₁ aflatoxin and also recognizes aflatoxins G₁, B₂, and the KLH protein. No cross-reaction is observed with aflatoxins and B_2a, G₂, G_2a, M₁.

Aflatoxins are highly carcinogenic.

Aflatoxins are highly toxic mycotoxins produced by the fungus Aspergillus. Aflatoxins are commonly found in various grains and peanut butter.

Mycotoxins, a group of chemically diverse secondary fungal metabolites, induce a variety of toxic responses in humans and animals when food and feed containing these compounds are ingested. Rapidly quantitating levels of mycotoxin contamination can help reduce exposure to these toxins.

Aflatoxin B₁ is the most abundant and significant member of the group, which includes B₂, B_2a, G₁, G_2a, M₁, M₂, P₁, Q1, aflatoxicol I (natural isomer), aflatoxicol II (unnatural isomer), tetrahydrodeoxy aflatoxin B1, and the unstable reactive B₁ (8,9)-epoxide.

Immunogen

aflatoxin B₁-KLH.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Specificity

Sensitivity range for this product is 0.005-20 ng/ml of aflatoxin B₁.