Application

Amitriptyline hydrochloride has been used:as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) miceas a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human bloodas an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia. It possesses antihistaminic, anticholinergic, and antiserotonimicproperties. Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.

Features and Benefits

Shelf-life of the powder is at least three years.