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N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide, >=98% (HPLC), solid

Code: b3436-5mg D2-231

Biochem/physiol Actions

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Hunti...


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Biochem/physiol Actions

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.

assay≥98% (HPLC)
coloroff-white
formsolid
InChI keySJJKUNDBFWUAQB-UHFFFAOYSA-N
InChI1S/C19H14Br2N2O3S/c20-14-4-8-16(9-5-14)22-19(24)13-2-1-3-18(12-13)27(25,26)23-17-10-6-15(21)7-11-17/h1-12,23H,(H,22,24)
Quality Level100
SMILES stringBrc1ccc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3ccc(Br)cc3)cc1
solubilityH2O: insoluble, DMSO: ~20 mg/mL
storage temp.2-8°C
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B3436-25MG
N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide, >=98% (HPLC), solid

Unit:25MG
List Price: £642.00
Source:List Price
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Cas Number300670-16-0
This product has met the following criteria: