5Z-7-Oxozeaenol, >=98% (HPLC)

Code: o9890-1mg D2-231

Application

5Z-7-Oxozeaenol has been used:as transforming growth factor β-activated kinase 1 (TAK1) inhibitor to treat human colon cancer cellsas TAK1-specific inhibitor to p...


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£224.00 1MG
£268.80 inc. VAT
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Application

5Z-7-Oxozeaenol has been used:as transforming growth factor β-activated kinase 1 (TAK1) inhibitor to treat human colon cancer cellsas TAK1-specific inhibitor to provide intraperitoneal injection to mice for aortic bandingas TAK1 inhibitor to treat cells for luciferase reporter assayto test growth and differentiation factor 2 (GDF2)-mediated anoikis

Biochem/physiol Actions

The anti-inflammatory effects of 5Z-7-oxozeaenol may affect cardiac hypertrophy.

5Z-7-oxozeaenol is a potent ATP-competitive irreversible inhibitor of ERK2 (IC50 = 80 nM), TAK1 (MEKK7), MKK7, and MEK1, which all contain a common cysteine residue in the ATP-binding site. 5Z-7-oxozeaenol has no activity against other MAP kinases. 5Z-7-oxozeaenol is also anti-inflammatory.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the MAPKKKs and MAPKs pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

1 mg in glass bottle

assay≥98% (HPLC)
colorwhite to off-white
formpowder
InChI keyNEQZWEXWOFPKOT-BYRRXHGESA-N
InChI1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1
Quality Level100
SMILES stringCOc1cc(O)c2C(=O)O[C@@H](C)CC=CC(=O)[C@@H](O)[C@@H](O)CC=Cc2c1
solubilityDMSO: >10 mg/mL
storage temp.2-8°C
Cas Number253863-19-3
This product has met the following criteria to qualify for the following awards: