Application

Pilsicainide hydrochloride has been used as a sodium channel blocker:to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparationto study its effects on Ca²⁺release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytesto study its electrophysiological effects on the guinea pig atrium

Biochem/physiol Actions

Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na⁺¹ channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(⁺) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.

Features and Benefits

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Packaging

10, 50 mg in glass bottle