Picrotoxin, powder

Code: p1675-5g D2-231

Application

Picrotoxin has been used:as non-competitive antagonist for the γ-aminobutyric acid (GABAA) for studying synchronized burst (SB) dynamicsas a component ...


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Application

Picrotoxin has been used:as non-competitive antagonist for the γ-aminobutyric acid (GABAA) for studying synchronized burst (SB) dynamicsas a component of extracellular saline for blocking glutamate and acetylcholine receptors in neuronsas a component of artificial cerebrospinal fluid (ACSF) for voltage-clamp recordings studies in dissociated cortical neurons

Biochem/physiol Actions

GABAA receptor antagonist; binds to the GABA receptor-linked Cl− channel.

Picrotoxin is a competitive inhibitor of glycine receptors (GlyRs). It is a non-competitive antagonist, which binds to ligand bounded γ-aminobutyric acid (GABAA) receptor.

Features and Benefits

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

Picrotoxin is isolated from moonseed family, Menispermaceae. It is a stimulant and may cause convulsions. It is an allosteric modulator of γ-aminobutyric acid (GABAA) receptor.

Other Notes

Molecular complex (1:1) of picrotin and picrotoxinin.

Packaging

1, 5 g in glass bottle

colorwhite
formpowder
Gene Informationhuman ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)
InChI keyVJKUPQSHOVKBCO-NGKRNLQBSA-N
InChI1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7+,8+,9-,13-,14-,15+;6-,7+,8+,9+,10-,13-,14-,15+/m11/s1
mp203 °C (lit.)
Quality Level200
SMILES string[H][C@@]12C[C@@]3(O)[C@@]4([H])[C@H](C(C)=C)[C@]([H])(OC4=O)[C@@]5([H])OC(=O)[C@]1(O2)[C@@]35C.[H][C@@]67C[C@@]8(O)[C@@]9([H])[C@@H]([C@]([H])(OC9=O)[C@@]([H])OC(=O)[C@]6(O7)[C@@]8C)C(C)(C)O
Code
Description
Unit Size
List Price
Qty
P1675-1G
Picrotoxin, powder

Unit:1G
List Price: £39.60
Source:List Price
ADD
Cas Number124-87-8
Hazard Class6.1
Un Number3462
Pack GroupII
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