Application

PD 98,059 has been used:in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptorsin calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdownin culture medium for cell migration assay

Biochem/physiol Actions

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold with permission of Warner Lambert Company.

Packaging

1, 5 mg in glass bottle