Application

Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions². Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay³.

Biochem/physiol Actions

Weak diuretic with potassium sparing properties; blocks Na⁺ reuptake in the kidneys.

Features and Benefits

This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.