Application

Clozapine N-oxide has been used:for the activation of human M4 muscarinic (hM4Di) in primary motor cortexfor inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic micein behavioral testing in mice and for stimulating (HEK293) cells

Biochem/physiol Actions

5-HT₂ serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.

Features and Benefits

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General description

Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.

Packaging

5 mg in glass bottle