Application

Azoxymethane (AOM), a gene mutation agent, may be used with dextran sulfate sodium (DSS) to create cancer models in laboratory animals which can be used to study mechanisms of cancer progression and chemoprevention.

Biochem/physiol Actions

Carcinogen that induces O⁶-methylguanine adducts in DNA leading to G→A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.

Other Notes

It is critical to determine the correct dosage of Azoxymethane for the experimental design to avoid premature death of laboratory animals.

Packaging

25, 100 mg in ampule