Analysis Note

Freely soluble in water, practically insoluble in acetone and in ethanol (96%)

Application

Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii . It has been used to study hephrotoxicity in the rat kidney , and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa .

Biochem/physiol Actions

Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.Antimicrobial spectrum: Gram-negative bacteria.

Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity. Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH .

General description

Chemical structure: peptide

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Packaging

100 mg in poly bottle

1 g in poly bottle