1,4-Naphthoquinone, purum, >=96.5% (HPLC)

Application

1,4-Naphthoquinone is the key structural moiety of many anticancer and antifungal agents. It can be used to synthesize:3,3-Disubstituted oxindoles via asymmetric Michael addition to oxindole. Bioactive isoindolines via asymmetric 1,3-dipolar cycloaddition to azomethine ylides generated in situ from aldehydes and diethyl aminomalonate. α,α-Difluoro-β-hydroxy ketone via ‘;on water’; catalyst-free Mukaiyama-aldol reaction with difluoroenoxysilane. 2-Hydroxy-3-anilino-1,4-naphthoquinone, which shows potent in vivo antimalarial activity. Additional appilcation include: As an arylation reagent for the α-arylation of aldehydes. As a starting material in the multi-step synthesis of benz[f]indole-4,9-diones.