Application
N,N′-Diisopropylcarbodiimide can be used: To synthesize lanthanide (Ln) guanidinate complexes via insertion of carbodiimide into the Ln-N bond of lanthanocene secondary amido complexes.To facilitate the cyclization of N-(β-Hydroxy)amides to form 2-oxazolines.To synthesize 1-isopropyl-2-alkoxycarbonyl-3-isopropyliminio-aziridine by reacting with alkyl diazoacetates in the presence of transition metal salts.
DIC can be used as: A coupling reagent for the synthesis of various esters and amides by treating carboxylic acids with phenols and amines respectively. A reagent for the conversion of alcohols to aldehydes or ketones in the presence of DMSO via modified Moffatt-type oxidation reaction. A reagent to facilitates the preparation of alkyl halides from corresponding alcohols via the formation of o-alkylisourea.
Alternative to dicyclohexylcarbodiimide in peptide synthesis.
General description
N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.
This product has met the following criteria: