Application
Adenosine 5′-diphosphate disodium salt has been used as a purinergic G protein-coupled receptor P2Y12 agonistin platelet activation tests in blood samples.
Biochem/physiol Actions
Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by ATP synthases. ADP affects platelet activation through its interaction with purinergic receptors P2Y1 and P2Y12. Upon its conversion to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.
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