Application

Poly(cytidylic-inosinic) acid potassium salt has been used:in pretreatment to understand Con A-induced hepatitis in micein RNA extraction from hemolymph plasma for qPCR detection assayto induce inflammatory changes in liveras a component of minimal essential medium for the stimulation of rainbow trout gonad line RTG-2 cells

Biochem/physiol Actions

Poly(cytidylic-inosinic) acid, poly I:C mimics viral RNA to induce immune response. Administration of poly I:C promotes cytotoxic functionality of natural killer cells and macrophages. However, poly I:C may trigger generation of anti-mitochondrial antibodies (AMAs) and contribute to the pathogenesis of primary biliary cirrhosis (PBC). Poly I:C may play a hepatoprotective role in Con A-induced T cell-dependent liver injury.

Poly(cytidylic-inosinic) Poly(C,I) is a random copolymer of inosine and cytidine bases which may be useful for comparative physicochemical analysis versus other random copolymers such as Poly(C,A), Poly(C,U) and Poly(C,G).

Other Notes

Random copolymer

Packaging

5 mg in glass bottle

10 mg in poly bottle