Application

Poly(deoxyguanylic-deoxycytidylic) acid (Poly(dG-dC) • Poly(dG-dC)) is an alternating copolymer, self-complementary, double-stranded DNA model for conformational studies of DNA structure dynamics and drug interaction.

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt has been used:in electrophoretic mobility shift assay of transcription factor IIIB complexas synthetic copolymers for circular dichroism (CD) spectroscopy studiesas a positive control in liquid scintillation counting

General description

Poly(deoxyguanylic-deoxycytidylic) acid (poly(dG-dC)) undergoes salt dependent conformational transition. Under high-salt, it exists as a left-handed double helix and at low-salt it displays B-DNA conformation. However on immobilization, poly(dG-dC) takes up A DNA form.

Other Notes

Alternating copolymer; self-complementary, form double-stranded complex

Unit Definition

One unit will yield an A₂₆₀ of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1cm light path).