Application

6-Azauridine has been used:in uridine monophosphate synthase (UMPS) activity assayas an antiviral agent to study its inhibition effect and cytotoxic potential on foot and mouth disease virusto screen for anticryptosporidial activityin the pretreatment of HeLa cells to study its effect on inhibition of cellular uridine synthesis before and during chase with 5-bromouridine 5′-triphosphate (BrUTP)as a reference compound for comparing the antiviral activity and cytotoxic activity against viral host cell lines

6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP and it is used in antiviral studies.

Biochem/physiol Actions

6-azauridine is a prodrug, upon conversion to 6-aza-UMP, inhibits uridine monophosphate synthase (UMPS). It is a broad spectrum anti-metabolite. It interferes with pyrimidine biosynthesis and affects the cellular nucleic acid levels. It is considered as a antineoplastic metabolite. It inhibits RNA viruses like chikungunya virus, semliki forest virus, and human coronavirus. It significantly inhibits the growth of Cryptosporidium parasites.

General description

6-Azauridine is a pyrimidine nucleoside analog.

Packaging

1, 5 g in poly bottle