5-Deoxyadenosine, methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase substrate

Code: d1771-25mg D2-231

Application

5′-Deoxyadenosine has been used:as a standard in mass spectroscopyas an inhibitor for screening thymidine phosphorylase activityas a substrate in 5′-Deoxyadenosin...


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£219.00 25MG
£262.80 inc. VAT
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Application

5′-Deoxyadenosine has been used:as a standard in mass spectroscopyas an inhibitor for screening thymidine phosphorylase activityas a substrate in 5′-Deoxyadenosine deaminase (DadD) assay

Biochem/physiol Actions

5′-Deoxyadenosine is a substrate for the enzyme methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase in microbes. 5′-Deoxyadenosine is a byproduct of cleavage of S-adenosylmethionine (SAM). High levels of 5′-Deoxyadenosine inhibits SAM dependent enzymes. It also inhibits biotin synthase (BioB) and lipoyl synthase (LipA) enzymes.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D1771.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Packaging

25 mg in glass bottle

assay≥98% (TLC)
formpowder
InChI keyXGYIMTFOTBMPFP-KQYNXXCUSA-N
InChI1S/C10H13N5O3/c1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15/h2-4,6-7,10,16-17H,1H3,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
Quality Level200
SMILES stringC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
solubilityhot water: 19.60-20.40 mg/mL, clear, colorless
storage temp.2-8°C
Cas Number4754-39-6
This product has met the following criteria: