n1630-1g

Application

β-NADPH is suitable for use in:desaturation of fatty acidsan assay of desaturase activitythe histochemical detection of NADPH diaphorase activity in rat, rabbit and pheasant thoracic spinal cordthe measurement of glutathione in oligodendrocyte cultures

Biochem/physiol Actions

NADPH is an electron donor and a cofactor for many redox enzymes including nitric oxide synthetase.

β-NADPH is the reduced form of NADP⁺ generated by the pentose phosphate pathway. It serves as a carrier of reducing power and transfers H⁺ and 2 e^– to the oxidized precursors in the reduction reactions of biosynthesis. It is an essential coenzyme for the catalytic activity of enzymes such as glutathione reductase, diacetyl reductase, dihydrofolate reductase, glutamic dehydrogenase, p-hydroxybenzoate hydroxylase, NADPH-FMN oxidoreductase, nitrate reductase, and thioredoxin reductase. It is also a part of cytochrome P₄₅₀ electron transport systems.

Other Notes

Packaged based on solid weight.

Packaging

1, 5 g in poly bottle

25, 50, 100, 250, 500 mg in poly bottle

Preparation Note

Chemically reduced.

assay	≥93% (HPLC), ≥93% (spectrophotometric assay)
form	powder
InChI key	WYWWVJHQDVCHKF-MPUNMZHWSA-J
InChI	1S/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;;;/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);;;;/q;4*+1/p-4/t10-,11+,13-,14+,15-,16+,20-,21+;;;;/m0..../s1
Quality Level	300
SMILES string	[Na+].[Na+].[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@H]2O[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](OP([O-])([O-])=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@H](O)[C@@H]2O
solubility	10 mM NaOH: soluble 50 mg/mL, clear
storage temp.	−20°C