Application

Albumin from human serum has been used:as a carrier of CPT-11 (irinotecan, Campto) and SN-38 to investigate its binding to human plasma proteinsto study the adsorption of water and acetonitrile (AN) vapor on a human serum albuminto study its effect on wound healing process

Biochem/physiol Actions

Serum albumin primarily mediates divalent cation transportation, fatty acid and drug complex formation and transport. The albumin levels in the serum indicate the disease progression in advanced liver disease. Low body weight and decreased serum albumin is associated with colorectal cancer.

Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function.

General description

Albumin is the most abundant plasma protein in human. It has a molecular weight of 66.5 kDa.

Other Notes

View more information on human serum albumin.

Packaging

100, 500 mg in poly bottle

1, 5, 10, 25 g in poly bottle

Preparation Note

Prepared from albumin (A1653)