Amino Acid Sequence

Gly-Pro-Arg-Pro-NH2

Application

Gly-Pro-Arg-Pro amide has been used-as a constituent of buffer during fluid-phase and bound thrombin inhibition assays, to determine the activity of thrombinfor blocking fibrin polymerization and preventing fibrin clot formation in presence of α-thrombin, in blood obtained from miceduring preparation of human soluble fibrin, to block the polymerization of soluble fibrin

Biochem/physiol Actions

Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).

General description

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.