Brain-derived neurotrophic factor (BDNF) is a member of neurotrophin family and plays a crucial role in neural development, maintenance, and function. It stimulates neurogenesis and is also a major regulator of synaptic plasticity and neuroprotection. It is used to maintain neurons and differentiate and mature human pluripotent stem cell-derived neural progenitors to cortical and motor neurons and cortical organoids.
Recombinant human BDNF protein has a molecular weight of 14 kDa. This protein is animal origin-free, carrier-free, tag-free, and non-glycosylated to ensure its purity with exceptional lot-to-lot consistency. Qk050 is suitable for the culture of reproducible and high-quality cortical and motor neurons and cortical organoids.
- High purity human BDNF protein (Uniprot: P23560)
- >98%, by SDS-PAGE quantitative densitometry
- 14 kDa
- Expressed in E. coli
- Animal origin-free (AOF) and carrier protein-free
- Manufactured in our Cambridge, UK laboratories
- Lyophilised from acetonitrile, TFA
- Resuspend in 10mM HCl, prepare single use aliquots, add carrier protein if desired and store frozen at -20°C or -80°C