Growth differentiation factor 5 (GDF-5) plays a crucial role during embryonic development and tissue homeostasis and is specifically involved in the development of the skeletal system. Recombinant human GDF-5 protein is commonly used for the differentiation and maintenance of induced pluripotent stem cells, embryonic stem cells, or bone marrow-derived mesenchymal stem cells into osteoblasts and chondrocytes.

Human GDF-5 is a dimer with a molecular weight of 27 kDa. This protein is animal origin-free, carrier protein-free, and tag- free with exceptional lot-to-lot consistency. GDF-5 is suitable for reproducible and high-quality chondrocytes and osteoblasts.

• High-purity human protein (UniProt number: P43026)
• >98%, by SDS-PAGE quantitative densitometry
• Expressed in E. coli
• 27 kDa monomer
• Animal origin-free (AOF) and carrier protein-free
• Manufactured in Cambridge, UK
• Lyophilised from acetonitrile/TFA
• Resuspend in 10mM HCl, prepare single-use aliquots, add carrier protein if desired and store frozen at -20°C or -80°C