CDK3/CyclinE1, active, GST tagged human, PRECISIO Kinase, recombinant, expressed in baculovirus infected Sf9 cells, >=70% (SDS-PAGE), buffered aqueous glycerol solution

Code: c1124-10ug D2-231

Biochem/physiol Actions

CDK3/CyclinE1is a member of the cyclin-dependent protein kinase family and promotes entry into S phase, in part by activating members of the E2F famil...


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Biochem/physiol Actions

CDK3/CyclinE1is a member of the cyclin-dependent protein kinase family and promotes entry into S phase, in part by activating members of the E2F family of transcription factors. CDK3 can also associate with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. The CDK3 gene has been mapped to chromosomal location of 17q22-qter, telomeric to the BRCA1 gene by somatic cell hybrids analysis. The presence of a single point mutation in the CDK3 gene from several Mus musculus strains commonly used in the laboratory has been reported.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

assay≥70% (SDS-PAGE)
formbuffered aqueous glycerol solution
Gene Informationhuman ... CCNE1(898), CDK3(1018)
mol wtCDK3 subunit ~60 kDa, cyclin E1 ~73 kDa
product linePRECISIO® Kinase
Quality Level200
recombinantexpressed in baculovirus infected Sf9 cells
shipped indry ice
specific activity17-23 nmol/min·mg
storage temp.−70°C
UniProt accession no.Q00526, P24864
This product has met the following criteria: