Membrane-bottom polypropylene filter plates bring convenience and speed to sample filtration on a microliter to milliliter scale. The individual sample wells or chambers have separate high-strength single or dual filter membranes to provide rapid filtration rates and to eliminate leakage or cross-talk between adjacent wells. All filter plates feature rigid polypropylene construction for chemical resistance and low binding and meet SBS footprint for use in robotic systems. Standard filter membranes include: glass fibre, PVDF polypropylene, polyethylene and polyethersulfone. Patent pending sealing process guarantees no well-to-well cross talk or weeping and allows superior recovery performance.